What Causes Akathisia : The NeuroChemical Explanation (Neuroleptic/AntiPsychotic-Induced and Anti-Depressant Induced)

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1. The most common cause, biologically, is excessive Serotonin (5-HT) activity. It can be caused by supplementing 5-HTP or simply intaking too much tryptophan in the diet with your antipsychotic drug and / or because of use of an SSRI-antidepressant with the neuroleptic-medication. The problem comes from the 5-HT2A Receptor/s. (1) (2) (3)
2. Too much blockade at post-synaptic Dopamine  D(2)L Receptors leads to akathisia as well as dyskinesia (4) (5) (6).
3. GABA-Receptor Deficiency and / or GABA deficiency may lead to Predisposition.... this is also evidenced in Benzodiazepine and / or Gabapentin treatment of ExtraPyramidal (EPS) side-effects from neuroleptics and SSRI's as well as other Psych-meds. (7) (8) (9) (10)..
4. Low Plasma (Blood) Iron (mineral) levels and thus, Iron-deficiency leads to akathisia and the most common predisposition/contributing factor to akathisia's. (11) (12) (13) (14)
5. Vitamin B6 at high doses has been found to alleviate akathisias since it modulates dopaminergic/serotonergic neurotransmission; favoring dopaminergic neurotransmission.{the best brand of B6 for antipsychotic/neuroleptic akathisia is Solgar, because it is HPLC-Verified (tested independently and analyzed by a lab}.

***OTHER NOTES***

• Fluvoxamine (Luvox) is one of the Only SSRI-medications that DON'T cause akathisias - and that is because it activates sigma-1 receptors which leads an overall enhancement of GABA release as well as other favorable neurotransmitter changes.