Serotonin's 1A receptor comes in two forms, for those of you who don't know... The Pre-Synaptic receptor which acts as an 'autoreceptor' thereby decreasing serotonin release (1) as well as GABA (2) (3) and glutamate (4) - and the post-synaptic receptor....the post-synaptic 1A receptor, when activated; often causes anxiety(5), trouble falling asleep(6), cognitive difficulties(7), and in some cases, psychosis and obsessive-compulsive behavior(8) (9). That's not to say it doesn't ever* have a positive role...but the antagonism of it is ideal for those who suffer from stress related issues and insomnia.
Additionally, it seems the post-synaptic side is a functional inhibitor of the nitric oxide - NMDA pathway (10) (11) which explains why excessive activity at this receptor can dampen libido, motivation and sex hormone production.
Now I don't know the EXACT affinity of the following products at that site, but I can tell you that they definitely help sleep and they help to blunt / remove sleeplessness caused by pro-serotonin supplements etc
Although it's on very rare occasion I use anything serotonergic and so it was more of a telling experiment in this case to do so.
Here is a study showing SPINOSIN, a component of ziziphus spinosa (WILD JUJUBE) can antagonize post-synaptic 5-HT1A receptors, alleviate anxiety caused by serotonin at that receptor, and promote sleep.
It can be bought below , but it also has GABA-A promotive action so it is not solely a serotonin antagonist. The other benefit is that Wild Jujube also antagonizes 5-HT1B receptors (12) and this also would provide an anti-anxiety action .
Additionally, it seems the post-synaptic side is a functional inhibitor of the nitric oxide - NMDA pathway (10) (11) which explains why excessive activity at this receptor can dampen libido, motivation and sex hormone production.
Now I don't know the EXACT affinity of the following products at that site, but I can tell you that they definitely help sleep and they help to blunt / remove sleeplessness caused by pro-serotonin supplements etc
Although it's on very rare occasion I use anything serotonergic and so it was more of a telling experiment in this case to do so.
Here is a study showing SPINOSIN, a component of ziziphus spinosa (WILD JUJUBE) can antagonize post-synaptic 5-HT1A receptors, alleviate anxiety caused by serotonin at that receptor, and promote sleep.
It can be bought below , but it also has GABA-A promotive action so it is not solely a serotonin antagonist. The other benefit is that Wild Jujube also antagonizes 5-HT1B receptors (12) and this also would provide an anti-anxiety action .
The next post-synaptic 1A antagonist would be berberine(13), berberine has strong use as both a blood sugar stabilizer and male aphrodisiac(14).
