...
Some of the Symptoms of high / too much GABA will very closely mirror low Glutamate symptoms | 1 |. Most of it will pertain to mental health and cognitive issues |2| |3| as evidenced by the effects of benzodiazepines on mentality |4| and alike to a moderate degree of intoxication |5|. Because GABA opposes cholinergic `(of acetylcholine) |6|, glutamatergic (of glutamate) |7| and dopaminergic/noradrenergic (of dopamine and noradrenaline) |8| |9| neurotransmission, excess GABA will also closely mirror deficiencies of each of those neurotransmitters.
The GABAergic `controls`` are the brakes on several cognition promoting neurotransmitters, however, GABA plays beneficial roles in mood and memory as well |10|, particularly in releasing growth hormone |11|, and in promoting nerve growth in some instances |12|. It also reduces cortisol secretion/release, which can have important anti-stress effects |13| |14|.
Despite this, having excessive GABA will negatively impact a number of cognitive functions and will especially influence nitric-oxide release ....
SO, WHAT Are The Signs of `Too High`` GABA?? Excess GABA Symptoms include...
ROLE OF GABA IN MEMORY AND ANXIETY - DEPRESSION AND ANXIETY 4:100–110 (1996/1997)
The Role of
Benzodiazepines
in the Treatment of
Posttraumatic Stress
Disorder (PTSD)
GABA & Memory - Bodybuilding.com Discussion
Prim Care Companion J Clin Psychiatry. 2005; 7(1): 23–32.
PMCID: PMC1076447
Benzodiazepines: Revisiting Clinical Issues in Treating Anxiety Disorders
Immunopharmacol Immunotoxicol. 1998 May;20(2):199-209.
Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.
Drugs. 1985 Jun;29(6):570-81.
Adverse neuropsychiatric effects of anticonvulsant drugs.
Brain glutamate deficiency in amyotrophic lateral sclerosis
Thomas L. Perry, MD, Shirley Hansen, BA and Karen Jones, BSc
Sleep. 2008 Mar 1; 31(3): 342–347.
PMCID: PMC2276749
Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy
Dialogues Clin Neurosci. 2006 Dec; 8(4): 383–395.
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Sean M. Smith, PhD
Sean M. Smith, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Wylie W. Vale, PhD*
Wylie W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Author information ► Copyright and License information ►
Michael W. King, PhD: The BioChemistry of Neurotransmitters and Nerve Transmission : GABA
Some of the Symptoms of high / too much GABA will very closely mirror low Glutamate symptoms | 1 |. Most of it will pertain to mental health and cognitive issues |2| |3| as evidenced by the effects of benzodiazepines on mentality |4| and alike to a moderate degree of intoxication |5|. Because GABA opposes cholinergic `(of acetylcholine) |6|, glutamatergic (of glutamate) |7| and dopaminergic/noradrenergic (of dopamine and noradrenaline) |8| |9| neurotransmission, excess GABA will also closely mirror deficiencies of each of those neurotransmitters.
The GABAergic `controls`` are the brakes on several cognition promoting neurotransmitters, however, GABA plays beneficial roles in mood and memory as well |10|, particularly in releasing growth hormone |11|, and in promoting nerve growth in some instances |12|. It also reduces cortisol secretion/release, which can have important anti-stress effects |13| |14|.
Despite this, having excessive GABA will negatively impact a number of cognitive functions and will especially influence nitric-oxide release ....
SO, WHAT Are The Signs of `Too High`` GABA?? Excess GABA Symptoms include...
- Impaired Short-Term Memory |!|
- Impaired Coordination |!|
- Impaired Working Memory |!|
- Impaired Spatial Memory |!|...
- Low Motivation |!|
- Disinhibition |!|
- Irritable Dysphoria |!|
- Apathy |!|
- Delirium |!|
- Odd Behavior |!|...
- No / Little Restraint on Own Words |!|
- Excessive Dependence on Stimulants |!|
- Little Capacity for Emotional Connections |!|
- Intolerance to Alcohol, or Strong Sensitivity to Alcohol and Other Sedatives |!|
- Dilated Pupils |!|
- Aggressive Behavior |.......|
- Low Libido / Low Sex Drive / Absent Sex Drive / Absent Libido |!|
IN BLOOD WORK / ENDOCRINE READ-UPS
- Low ACTH & Cortisol in Blood. |!|
- Secondary Hypogonadism if the GABA excess is genetic, and severe |!|
- Significant norepinephrine deficiency in blood work, and low whole blood glutamic acid levels |!| |!``!|.
SUGGESTIONS TO LOWER A HIGH/EXCESS GABA LEVEL
- Supplement with L-Histidine, which converts into histamine, which is a neurotransmitter that reduces excessive GABA. |!| |!`!|
- Supplement with Ginkgo Biloba Extract, which can antagonize moderately, the GABA-A Receptor |!| |/!!\|.
- EXERCISE!! Exercize may reduce excessive inhibitory neurotransmission by temporarily increasing noradrenaline/sympathetic nervous transmission, so do it often, for at least 30 mins to an hour! You'll feel better, Trust me!
** SUPPORTING REFERENCES **
ROLE OF GABA IN MEMORY AND ANXIETY - DEPRESSION AND ANXIETY 4:100–110 (1996/1997)
The Role of
Benzodiazepines
in the Treatment of
Posttraumatic Stress
Disorder (PTSD)
GABA & Memory - Bodybuilding.com Discussion
Prim Care Companion J Clin Psychiatry. 2005; 7(1): 23–32.
PMCID: PMC1076447
Benzodiazepines: Revisiting Clinical Issues in Treating Anxiety Disorders
Immunopharmacol Immunotoxicol. 1998 May;20(2):199-209.
Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.
Drugs. 1985 Jun;29(6):570-81.
Adverse neuropsychiatric effects of anticonvulsant drugs.
Thomas L. Perry, MD, Shirley Hansen, BA and Karen Jones, BSc
Sleep. 2008 Mar 1; 31(3): 342–347.
PMCID: PMC2276749
Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy
Dialogues Clin Neurosci. 2006 Dec; 8(4): 383–395.
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Sean M. Smith, PhD
Sean M. Smith, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Wylie W. Vale, PhD*
Wylie W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Author information ► Copyright and License information ►
Michael W. King, PhD: The BioChemistry of Neurotransmitters and Nerve Transmission : GABA
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