Can Someone Live Without Serotonin? (Short-Answer & In-Depth Explanation) (Possible Symptoms Included)

Short-Answer : Yes. But one may need to still supplement with Melatonin if Serotonin is unable to be produced in the brain/body.

**There may be significant alterations in synaptic plasticity, altered cognition, constipation and abnormal aggression, as well as odd developments in neural fibers and skeletal mass ([but not bad, necessarily])**

                               `~~~GOING FURTHER~~~`
Sepiapterin Reductase Deficiency is a condition which causes a loss of monoamine neurotransmitters; like Serotonin and Dopamine - one case, where a 28-year old Man was studied in France with this particular genetic mutation ,,,  showed that low levels of Serotonin, AFTER dopamine deficiency was reversed with L-Dopa treatment - revealed no significant Depressive-symptoms..BEFORE & AFTER - Interestingly, the man who had virtually no serotonin or dopamine; he slept WAY TOO MUCH; so I guess that puts a wrench in the  Prozac Pusher's Happy {medium}. You know, they go off saying "Serotonin is good for Sleep" .... ''good for depression/mood''.

Nothing is that simple in brain chemistry, EVER.

• Serotonin Depletion *usually* causes some degree of behavioral changes in all study types/subjects, however, some do not really show any significant changes.
• In HEALTHY Humans without a genetic/family history of Major Depressive Disorder; serotonin depletion does not cause any mood disturbance(!).
• In HEALTHY Humans with a genetic/family history of Depression - there is only a *slight* reduction in mood(!).
• It is demonstrated that low serotonin levels may induce gastrointestinal complaints (like Constipation), but otherwise do not prominently affect gut health if everything else is in check.
• Serotonin plays a LARGE role in vascular/heart health, however, much of the evidence points towards serotonin contributing to pulmonary hypertension/high blood pressure..
• Low Serotonin theoretically could lead to alterations in bone mass - but i t may, again, be irrelevant if the individual is healthy, otherwise (R1) (R2) (R3)