How Does Rabies (RV) Affect Neurotransmitters? What Neurotransmitters Does Rabies Affect?

.....

~Q~

How Does Rabies (RV) Affect Neurotransmitters?

What Neurotransmitters Does Rabies Affect?

~A~

1. It depletes cerebral noradrenaline/norepinephrine (NE) as well as Dopamine (DA) which leads to neuromuscular-dysfunction and abnormal thinking (1) (2). 
2. It also reduces GABA transporter efficacy and amplifies the release of GABA in response to potassium (K+) currents, this is likely responsible for the dissociative effects of the Virus (3) (4).
3. Rabies cleaves to and uses acetylcholine (ACh) receptors to spread and transfer it's presence to other neural domains, they also remain an incredibly important factor to the psychological effects of rabies, overstimulation of the nicotinic and muscarinic receptors plays a role in developing psychosomatic effects and possibly the convulsions at late stages (5) (6) (7)..
4. Finally, Rabies causes oxidative damage, a lot of which is attributed to a massive release of induced nitric oxide release, by the enzyme iNOS which means inducible nitric oxide synthase, this form is volatile, presence in .. cytoskeletal networks, and immune cells, as well as brain networks (8) (9) (10).

**OTHER REFERENCES/DISCUSSIONS***

• REDDIT: Why does rabies cause a fear of water?
• Rabies review: immunopathology, clinical aspects and treatment
• Rabies : Signs/Symptoms

~A Tribute to Self-Assurance and the Ultimate Preservation of Self~

† If there is one thing I have learned it is that the learned helplessness of this Society's , weaker portions, has become a justified madness. This is a major contribution to the overall weakening of Society on all levels. If we deem ourselves impermeable to change because we have assumed the fates of others by their Willing participation in this, learned weakness, then how Can we change the Society?

If our minds occupy a closed-off space in Reality, but if our minds create that space, then we too, are subject to that space, subject to nothingness in comparison, to those who live in fullness because of their learned flexibility. That flexibility though, tempered by the identification of methods , in Business, in the Art of Creating Ideas, and expanding them through the same. We are born useless to the outside eye, because it is expected that a good portion of us born into this dramatic society will fall into the erotomanic, disillusioned fraction of aimless beings.

Then there is the Project of Sanity, the Project of Learned Cooperation, the Project of Composure, there is that , lingering caution, meant to set us apart from our dreams, perhaps, Bravery, being determined as Grandiosity at times, or being seen as a disciple of madness, and Courage to Evil, because you see, we have inverted the core meanings, and we have done so by Face, by Image, by believing that all fierce characters are there to rip us off, we have seen this in our Political Campaigns as of late. We have seen the benevolence of Man being seen as Cowardis and feeble Character.

I would like to dispand this Idea , that , we must maintain integrity by means of volumous degradation of our true thoughts.

**... To collectivise our thoughts and then not let them permeate because ~{zZz}~  a few simpleton groups get offended is aggressive self-defeat, and so I offer a tribute for those who stand by self-assurance and their ultimate preservation of Self. ~^~^~ Because I stand for the new-age of Overt Open-Mindedness, one where Writers are not shamed for their ''strong stances'' on a topic or Two, one where people are freed from their inner voice and yet empowered by it, but certainly, I stand for the Peace of Mind that comes from total and Complete Freedom!!.



†

Factors Determining If One Will Get Side-Effects From Drugs (Why do Some People Get Side-Effects to Medications and Others Get None At All?)

This is another Area'1255 : "Questions & Answers" Chapter.

† Q †

Why do some People get side-effects from Medications & Others do Not?

† A †

Multiple factors play a role in drug side-effects. 

1. Because drugs often act upon certain proteins, enzymes, or receptors in the body, and attach often, quicker than natural molecules, and exert actions at higher rates in comparison to natural molecules, the 'side-effects' are simply 'direct actions' and manifestations of the potency of the drug. However, it occurs because of rapid physiological changes by the body , by the means of actions on the molecular targets of the drug. Some people who get more severe side-effects, are people who were at a lower setpoint and likely had severe deficiency in whatever chemical the drug is acting on, or an excess at whatever the drug is reducing/blocking.
2. General Health plays a large factor, for example, one is less likely to develop immune deficiencies to certain drugs if they are already very healthy. So medications that reduce white blood cells are often a result of their interactions with enzymes that may already be partially, or significantly impacted based on the current health of that individual. 
3. Histamine levels play a role in drug side-effects (!) , those with lower histamine levels may experience less side-effects to certain medications in general [see here]. Whereas high histamine levels may be potentially protective against drug side-effects in some circumstances, particularly regarding bradycardic drugs, histamine may protect against low heart rate induced by drugs <Reference>. Dietary changes aimed at reducing histamine levels and other inflammatory chemicals will not set in place immediately, so a lessening of drug side-effects should not be expected if one is only 1-6 months in to their ''healthy diet''. Rather, it is to be expected that if one eats very healthy, including tons of fruits, vegetables, and in general gets a great amount of nutrients, that 12 months in + will impact the responses to any insult or change within an organ or system of cell communications which a drug may impact.
4. People with low histamine will be particularly vulnerable to stimulants and medications that increase blood pressure | ! |. People with high histamine are vulnerable to any medication or substance that lowers blood pressure  [R1] | [R2]. Increased histamine levels may be beneficial and even crucial for those people taking SSRI's for Depression |!|. Histamines are necessary for those anti-depressants to work properly.
5. Levels of Sex-Hormones impact heart related side-effects of certain drugs, for example, Men with high levels of dihydrotestosterone and decent fitness level will likely NOT develop a 'long-QT-syndrome' from psychiatric and other QT-prolonging medications.+See Article Here/

Area-1255's Diet Plans : "The Resonance Diet" (A Dopamine-Boosting-Diet)

The Resonance Diet

By : Area-1255

The Resonance Diet is a diet intended to bring about an incredible enhancement of dopamine-release. It can help restore dopamine levels to youthful levels, and thus restore a state of bliss, energy, optimism, and general quality of life. This diet is comprised of foods that can be obtained pretty much everywhere in the World. They are largely common foods but in a specific proportion with certain spices. The spices do not need to be obtained through a special pharmacy, naturopath, or even a specific food store, they should be available at your local grocery store or supermarket. 

The diet is supported by science on multiple levels, and the studies herein provide more than sufficient evidence for each particular ingredient to be justified as a 'dopamine-booster'.

Additionally, these ingredients, each independently, can be considered partial aphrodisiacs. Together, the entire diet is very friendly to our most visual definition of passion and virility. 

Here is the diet, it does not have to be followed 100% to the Tee in terms of timing, but it should remain relatively unaltered as the specific proportions are important in creating the responses in the  dopamine-systems.

BREAKFAST

Begin your day with a solid breakfast, always. 

This part of the diet functions as a morning energy booster and should be eaten ideally between the times of 5:30 AM & 11:00 AM. The reason for this time range is that circadian rhythms are set in 'wake' mode during this Time (!).

Eat a bowl of almonds and oats, at least 12 almonds per bowl, and a cup of oats.

Oats contain high levels of amino-acids, and beta-glucan which helps regulate cholesterol (!). Oats also increase the production of prostaglandin's, which support Pituitary function, this is, in part, because of the GLA in Oats, a type of fatty-acid (!).

Almonds contain high levels of Tyrosine, which is converted by the body into Dopamine (!).

LUNCH

Lunch is your next best time to energize. You may not want to be too giggly if you have to get back to work, but you want the vibe of enthusiasm and persistence.

Eat a bowl of Soup, with Cayenne peppers or cayenne pepper powder, Garlic is optional. An Italian Wedding Soup is preferred, as it contains plenty of dopamine-boosting vegetables. It also contains a very good amount of Protein. I recommend this brand : Imagine Organic Italian Vegetables & Beans Soup.

Get some protein on the side, preferably some hot almonds, like Blue Diamond : Siracha & Habanero.

DINNER

This meal should be equally HOT as your lunch diet, the spicy boosts the dopamine [ See Here ]. Eat a good amount of cayenne (either a teaspoon, or half a teaspoon could work), with whatever you are eating, heck, even lop it on your steak!  

Eat AT LEAST 50 Grams of Protein in this meal..

It is extremely important you eat tons of protein in this meal. 

Doing this ensures growth-hormone and dopamine responses (1,2,3).

Those are the only specific macronutrient rules for this meal, but there is one other prerequisite, YOU MUST EAT BEETS WITH THIS MEAL.

Beets ensure a dose of dietary nitrates, which boost circulation, and nutrient delivery to target tissues, and they also contain betaine, which leads to a prominent mood-lifting effect [!]. Beets are also an amazing source of folic acid, an important B-Vitamin which is needed for the production of many neurotransmitters; including dopamine, glutamate, histamine and nitric oxide!

 | See HERE, and thanks for reading |

Alternative Ways to Lower Prolactin Levels (Alternative Methods to Decreasing Prolactin Levels)

We have written about reducing Prolactin mRNA with supplements, we have written about the symptoms of high Prolactin in Men, we have written about the importance of controlling Estrogen in order to Keep Prolactin down, and now, we are going to decipher the alternative methods of decreasing the Prolactin levels.

What is that method, the method to decrease Prolactin without the use of Dopamine agonists?
Well of course, dopamine agonists are a good choice, but some do not prefer them either due to personal reasons / beliefs, or due to the fear that they will become addicted / dependent on them, or perhaps, some feel there are too many side-effects associated with them. All of these can be valid reasons. I may not particularly agree with some of those reasons, but they can be indeed Valid.

Well let's get to it. As usual, a citation will be placed on the side of the particular solution, a reference Ight..

1. Method #1 : Perhaps the scientific obfuscations produced by the alternative scientific community, i.e small chapter bodybuilding communities, have made this less clear, the number one method in MEN to reduce Prolactin, assuming Estrogen is under control, is actually to Eat a Specific dopamine-boosting diet. Our Dopamine-boosting diet, nicknamed the 'Resonance Diet', fits all the criteria to increase dopamine exponentially, and to fulfill the energy of one's youthful brilliance with integrity and persistence. If you have ever wondered how I maintain my persistence, it's through intense self-discipline, an augmented diet, and a way of life. ;)
2. Method #2 : Andractim DHT Gel : Dihdydrotestosterone is a powerful male hormone, that, when applied in a Gel, can rapidly eliminate Prolactin issues from one's hormonal mainframe, and almost immediately reduce puffy nipples, minor male breast growth, and functional limitations in terms of mental libido and , well , male 'oomph'! < see source here > <new study here>
3. Method #3 : The third 'alternative method' to reducing  PRL (Prolactin) levels, is to EXERCISE!! With intensity! Just for your chest HARD!! Burn that fat! You do this, and you will quickly see your refractory period dissolve from your life, and soon, it won't be there at all. (maybe). You want to entertain tranquility? Fine, but make sure your head is Above the Water! Make sure you have the inner 'oomph to knock away the attempted presence of your best buddys wiggling' squirming , sub-par mentality. They aren't alpha, You Are!!! [do you really need a reference for this one? Click here!]
4. Method #4 : Mucuna Pruriens Extract is a cheap, quick, and relatively smell-friendly method of decreasing Prolactin by means of ingesting a Pill. | see Study here |
5. Method #5 : And finally, remember to shit yourself every now and then. You know, get so hyper that you want to figure out the chronology of 'Ye own Bowel Movement'sss...!! But really, don't leave yourself bland, you do gotta go then Go! Research does show that holding back your bowel movements can greatly affect your hormones, and 'going to the bathroom' actually advices your glands, relief is Good, Relief is Good...

The Importance of Controlling Estrogen In Order To Keep Prolactin Down (Do You Have To Reduce Estrogen To Get Prolactin To Go Down?)

Estrogen and Prolactin show a whacky relationship, when you increase Estrogen, Prolactin release is 'aggregated and allowed' [1]. When you have estrogen dominance, whether you are a male or a female, it doesn't matter, your libido and your sense of vitality is shot [2] [3]. Whether you are an Animal [4] , or a Human [5], the case is the Same. Estrogen dominance is a force to be reckoned with, but not the force we Want in our Bodies.

Yes ladies and gentlemen, Estrogen provokes the chronological responses relevant to Prolactin secretion, both in the breasts [6] and Pituitary [7]. Thus, estrogen being the main 'hormonal' provoker of PRL (Prolactin) release [8], it is absolutely ESSENTIAL we aim to reduce Estrogen (particularly E2; Estradiol) in Order to Put the Cuffs on Prolactin.

With almost every aspect of biology, particularly hormone systems of mammalian beings, there is a inhibition and stimulation system, aka brakes and gas [9]. While ''Dopamine'' may serve as the main ''brake'' on Prolactin release/response [10], Estrogen stands as the proliferative ''Go" Peddle.. [11]. By Proliferative, we are referring to its ability to remarkably do so within several different body systems, often producing cell growth and replication in many of them [12], and this doesn't help the picture if one is suffering from heart enlargement [13] , or breast cancer [14], hence why anti-estrogens are used for these diseases [15] [16]...

Now some Doc's would have you believe that these Female Hormones are some 'god-given' substance that promotes universal well-being, but they are not, they are Wrong (the ones that say that of course, not all docs). Evolutionarily , we are talking about a hormone that has always produced cell and tissue growth [17], but since when did we want men, males, growing breasts?

I didn't see that back hundreds of Years ago, did You!?

( I know that hair can serve as an obstruction for the hard of SEE'ing, but any idiot with half-a-brain can tell they 'aint got 'No Tits'!. )

Look, the point here is YES Fellas, we need to control Estrogen to prevent the negative ramnifications of Prolactin excess and Issues. Prolactin-Issues in general, can be easily abolished by applying Andractim gel to the Chest. Andractim is a transdermal gel that reduces Estrogen locally, and can be used to boost libido, and some use it for Penis enlargement.

[ Here's the study ya'D want to Read regardin' all That ]

So, it looks like we have all that settled, now lemme go get a bit to Eat before I return to the hundreds of questions I am e-mailed on the 'daily.

Oh, and here's a couple other fancy numerAled  , numbered, Sources for ya!
[18]                                                    [19]                                                 [20]

Symptoms of Low Serotonin Levels (Signs / Symptoms of Low 5-HT Function / Availability / Levels)

.....

5-Hydroxytryptamine (5-HT) , also known as SEROTONin , is a powerul ancient chemical within the body that provides feedback to several other neurotransmitters and neuromodulators.
About 90% of it is in the gut, however, the 10-12% of it that is in the Brain and Spinal Cord is incredibly important and responsible for a number of effects on behavior, mood, and motivation, and especially, cognition.

Originally, it was thought that based on the benefits of SSRI'S, and based on the brain serotonin turnover rates of suicide victims, that low serotonin was the incidence that precedes a lot of the depressive behavior, and the subsequent studies on both animal and human behavior relative to serotonin levels, seemed to confirm the hypothesis that serotonin elevations are healthy for body and mind and especially for alleviating depression and Anxiety.

However, the last 5-10 years has instead shown that the picture is a lot more complex, including that...

• Low Dopamine is more likely the cause of Depression, and that low Serotonin signaling is more likely a biochemical imbalance that relates back to both a dopamine deficiency but also a cortisol imbalance (ƒ).
• High Serotonin, not low serotonin, causes Anxiety; including G.A.D, social anxiety (!), obsessive-compulsive symptomology (!), and contributes to panic. Benzodiazepines like Klonopine, Ativan & Xanax also work by reducing serotonin activity (!)
• The observed efficacy of SSRI's is more likely a result of their interactions with other systems like BDNF, σ1-receptors (1) (2), and GABAergic interneurons (◊).
• That any other serotonin actions relevant to SSRI's may accrue during years and be related to individual protein changes including the serotonin transporter protein. (○)

Regardless, there are still some mental health and Physical symptoms that DO have a direct connection to low Serotonin levels.

Mental Health Symptoms of Low Serotonin

• Insomnia (3) (4) (this can happen with high serotonin as well, but for different reasons, low serotonin production can cause Insomnia by means of less melatonin availability, since serotonin is needed to convert into melatonin. High serotonin causes Insomnia by direct overstimulation of 5-HT1A/1B as well as 5-HT2A Receptors)
• Impulsive & Aggressive Behavior (5) (6) (not equivalent to religious rantings or objective-oriented arguments/attacks, in fact, elevated serotonin is correlated with 'cult-leader-mentality' , showing that there are differences in impulsive-aggressive biochemistry versus goal-oriented and belief-oriented behaviors)
• Reduced Fear-learning, Reduced Negative Responding to an Upcoming or Anticipated Negative Effect (7) (8) <-- Also includes reduced fear 'recognition'.....
• High Libido, increased sexual risk-taking (9) (10)..
• Strong Appetite, especially for carbohydrate foods, sugary soft-drinks and fatty foods like Bacon (11) (12) (13) (14)..
• Gambling, and Risk-Taking Behavior in General <see Here>
• Workaholicism or Perfectionism (!) (!) (though this can be explained by high serotonin as well, low serotonin types like things tidy, and visually orderly, and are more linear minded than high serotonin individuals, who often occupy a more scatterbrained environment)

Physical Symptoms of Low Serotonin

• Perhaps the most remarkable effect, or 'side-effect, of low serotonin, is Constipation (!) - as serotonin is heavily involved in gastrointestinal motility and enterokinetic nerve function (!) (!!).
• A Low, or High Heart Rate may be present with low serotonin, with a higher chance of being slightly faster than your average person (15) (16) (17) (18).
• Low or High Blood Pressure, depending on secondary factors, for example low serotonin and normal or low noradrenaline would equal hypotension or low-end of normal blood pressure, but low serotonin and high noradrenaline may lead to higher calcium entry into cells, which may lead to higher sympathetic nervous system activity and higher blood pressure. (19) (20)
• Migraine or Vascular Headaches [!] (( Not everyone will experience these effects, in fact, not even 30% may experience a migraine if they have no prior history of it, at least not without other factors setting in.))

SPECIFIC SEXUAL EFFECTS OF LOW SEROTONIN

• Premature Ejaculation (21) (22) (23)
• Increased ' Flaccid Hang ' Size (24) (25)
• Quick Sexual Arousal (26) (27)
• Loss of Selectivity in Partners, or Excessive / Persistent Experimentation with Sexual Acts (28) (29) (30) (31) (32) ...

SUGGESTIONS TO BOOST A LOW SEROTONIN LEVEL

1. Eat more Red Meat and / or Oats, as they contain a good amount of Tryptophan, Serotonin's main precursor. 
2. Supplement with an adaptogen supplement known to increase Serotonin levels, Super Rhodiola by Ceretropic is a great way to do this.

▌▌▌IMPORTANT SOURCES▌▌▌

Science Daily - Brain's Response To Fear And Stress Influenced By Number Of Serotonin Receptors

Alcohol, serotonin and aggression

The effects of acute tryptophan depletion
on heart rate variability in remitted
depressed patients

From Genes to Brain to Antisocial
Behavior

Behavioral/Systems/CognitiveImpaired Stress-Coping and Fear Extinction and AbnormalCorticolimbic Morphology in Serotonin TransporterKnock-Out Mice