Optimoterol - The debut of superior β2 receptor agonist/cardioselective β1 receptor antagonist Proprietary Blend-OA

Move over Clenbuterol and Welcome OptimoterolTM

The debut of superior β2 receptor agonist/cardioselective β1 receptor antagonist

proprietary ratio combination as an Optimized Agent format.

Potent and highly efficacious combination of Formoterol and Nebivolol in an optimized ratio format for research into the benefits of the potent β2 agonist Formoterol while using an optimum correlative dose of Nebivolol to promote minimized adverse effect potentials via cardioselective antagonism of β1 receptors.

Optimoterol

Optimized Agent design to provide the most superior efficacy and therapeutic index for the spectrum of benefits.

Research Indications:  Anti-Obesity/Lipolytic Research, Anabolic/Myotrophic Research, Neurogenic/Dendritogenic Research, Anti-Aging Research, Mitochondrial Research

Formoterol is a long-acting β2 agonist (LABA) that has an extended duration of action (up to 12 hours) compared to short-acting β2 agonists such as salbutamol, which are effective for 4–6 hours.

Nebivolol is a cardioselective β1 receptor antagonist with a mean half-life of about 12 hours.

Enhanced Muscular Hypertrophy and Anti-Obesity Potentials: Potent Lipolytic Effects with Concurrent Anabolic-Myotrophic Effects

β2 agonists increase energy utilization and fat metabolism, however, therepeutic use for obesity has been limited by the concomitant activation of β1 receptors resulting in excessive increases in heart rate. A recent 2012 dose-finding study (in healthy men) demonstrated significantly increased resting energy expenditure, and fat oxidation at a dose of 160 μg of formoterol per day without significantly increased heart rate. Formoterol's specificity for the β2 receptor (relative to β1 receptors) may facilitate its use for this purpose. A combination of a highly selective β2 agonist like formeterol with a low dose highly selective β1 blocker may further improve the differential therapeutic ability to selectively agonize β2 receptors for metabolic benefits in treating obesity without adverse β1 agonist effects.[1] The selective β1 blocker (β1 antagonist) Nebivolol at low doses results in fully cardioselective effects and demonstrates efficacy to abolish potential adverse effects of formoterol at higher doses. Nebivolol demonstrates antihypertensive vasodilatory effects as well.

As with other beta(2)-adrenoceptor agonist (beta(2)-agonist), formoterol, has been shown to cause muscle hypertrophy in rats even when administered at the micromolar dose of 25 micro g/kg/day. A similar low dose of formoterol as well improves muscle function in the dystrophic mdx mouse. The findings indicate formoterol has considerably more powerful anabolic effects on skeletal muscle than older generation beta(2)-agonists (like clenbuterol and albuterol), and has considerable therapeutic potential for muscular dystrophies and other neuromuscular disorders where muscle wasting is indicated. [2]

::  MECHANISM OF ACTION :: 

Beta-adrenergic agonists may help build muscle through two mechanisms.

1.) They may increase androgen signaling through induction of histone demethylase (!) (!) which leads to increases in androgen receptor signaling (!). When androgen receptor signaling is increased, protein synthesis, utilization and delivery is dramatically enhanced. Additionally, the anabolic benefits of androgen receptor activation may be furthered when glycogen uptake is improved, which also occurs with beta agonists.(!) 

2.) They inhibit myostatin, ESPECIALLY formoterol(!), have you seen the rats, swine, and cows who have myostatin genes deleted? They are hunormous! (!)

By inhibiting this enzyme, muscle growth is DISINHIBITED and other anabolic hormones are also then disinhibited. Thus, everything else you do will result in higher results and strength will be improved dramatically as muscle growth is accelerated. You see, because myostatin is an enzyme/protein complex that is almost solely around to control** muscle growth(!).

ANABOLIC EFFECTS ON BONE
Formoterol - may also have anabolic effects on bone and thus lead to expansion / growth of cortical bone , it may also , with long-term use - lead to increases bone mass and density(BMD/BDD).  (!) (!) (!)
The PKA/cAMP pathway leads to increases in osteocytes and osteoclasts and also increases enzymatic growth factors including IGF-1, Transforming Growth Factor and Bone Morphogenic Proteins. The complex alteration in signal transduction leads to widespread beneficial enhancement in growth factors both in bone and in some cartilage.

Anticachexic Potentials -  results indicate that formoterol exerted a selective, powerful protective action on heart and skeletal muscle by antagonizing the enhanced protein degradation that characterizes cancer cachexia, and it could be revealed as a potential therapeutic tool in pathologic states wherein muscle protein hypercatabolism is a critical feature such as cancer cachexia or other wasting diseases.

Neurogenic/Dendritogenic Potentials: Strengthening of Nerve Connections in Hippocampus

Preliminary research offers hope that formoterol may be a useful treatment in Down's Syndrome. In a mouse model of the disease, the drug strengthened nerve connections in the hippocampus, a brain center used for spatial navigation, paying attention and forming new memories. [4]
Beta agonists also have the ability to increase glutamate levels (!)  (!) and activity in cerebrocortical nerve terminals which may improve memory and mental performance. They also appear to do so safely.
In the central nervous system, adenylyl cyclases regulate many cellular processes in response to extracellular and intracellular signals such as hormones, neurotransmitters, and Ca2+ (1). Inmunohistochemical studies of adenylyl cyclase in the brain have shown a selective concentration at synapses both in presynaptic axon terminals and in postsynaptic densities (2). Consistent with this localization, the activation of adenylyl cyclase with forskolin has been shown to enhance synaptic transmission in hippocampal slices from CA1 (3, 4), CA3 (5, 6), and the dentate gyrus (7) as well as in neostriatal neurons (8). Moreover, the cAMP-dependent effects on synaptic transmission have been implicated in long-term potentiation in the hippocampus both in CA1 neurons (9) and in slices from the CA3 region (6, 10). Recently, evidence has been found indicating that the extracellular signal involved in the activation of this cAMP-dependent pathway is noradrenaline, acting via a β-adrenergic receptor. Thus, the β-adrenergic agonist isoproterenol has been shown to mimic the potentiating effects of cAMP elevation in synaptic transmission (11, 12).

Stimulation of mitochondrial biogenesis

Formoterol may also help stimulate mitochondrial biogenesis. Mitochondrial dysfunction is related to many degenerative diseases — particularly neurodegenerative disorders. Formoterol thus may provide potent an anti-aging longevity-healthspan promoting mitochondrial biogenesis.[5]
Additionally, formoterol being a beta-agonist, may improve thyroid hormone ratios and thus act on a neuro-endocrine level to boost cellular metabolism as well. Specifically the increase in cyclic adenosine monophosphate results in the rise of T4 hormones...which then leads to higher metabolic output and strengthening of both neuronal growth factors and cellular metabolism. (!) (!)

References:

[1] Lee, P; Day, RO; Greenfield, JR; Ho, KKY (May 29, 2012). "Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men". International Journal of Obesity 37 (4): 593–597. doi:10.1038/ijo.2012.90. ISSN 1476-5497. PMID 22641064

[2] Harcourt LJ1, Schertzer JD, Ryall JG, Lynch GS Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul Disord. 2007 Jan;17(1):47-55. Epub 2006 Nov 28.

[3] Busquets S1, Figueras MT, Fuster G, Almendro V, Moore-Carrasco R, Ametller E, Argilés JM, López-Soriano FJ. Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting. Cancer Res. 2004 Sep 15;64(18):6725-31.

[4] Dang, Van; Medina, Brian; Das, Devsmita; Moghadam, Sarah; Martin, Kara J; Lin, Bill; Naik, Priyanka; Patel, Devan; Nosheny, Rachel; Wesson Ashford, John; Salehi, Ahmad (27 June 2013). "Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome".Biological Psychiatry. doi:10.1016/j.biopsych.2013.05.024

[5] Wills, Lauren P; Trager, Richard E; Beeson, Gyda C; Lindsey, Christopher C; Peterson, Yuri K; Beeson, Craig C; Schnellmann, Rick G (April 6, 2012). "The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis". The Journal of Pharmacology and Experimental Therapeutics 342 (1): 106–118. doi:10.1124/jpet.112.191528.ISSN 1521-0103. PMC 3383035. PMID 22490378

Symptoms / Signs of Too Much Serotonin / Excess Serotonin {SPECIFICS, EASY TO READ, CITED}

Due to being increasingly displeased with the difficulty in finding such information; to the average user, I have compiled a well cited guide on determining if you may have TOO MUCH SEROTONIN.

One VERY important thing to remember, is that excessive serotonin production is NOT the only way to have high serotonin, and often...excessive serotonin is due decreased breakdown of serotonin and it's metabolites. This can occur when using SSRI's along with other medications or supplements that impact the breakdown of serotonin, such as MAO-A inhibitors (ST.John's Wort), Syrian Rue, Nutmeg etc

With nutmeg, it is unlikely you will get enough of a toxic effect from using a little of the whole spice, HOWEVER, if you are using teaspoon after teaspoon of nutmeg excessively, then EATING other foods that increase serotonin, like bananas and turkey - then you have an increased risk of developing serotonin syndrome.

KEEP IN MIND, that the symptoms related to serotonin syndrome represent a SEVERE excess of serotonin which often requires immediate care / CRISIS management.

TOO MUCH serotonin is describing a PERSISTENT, but NOT SEROTONIN-SYNDROME qualified excess. Therefore, this article is NOT describing serotonin syndrome, but too much serotonin* over time - where it relates to borderline health issues.

This article is ideal for those who suspect out of balance serotonin, but not so much serotonin that it becomes toxic as in an acute CRISIS. 

Some symptoms of high serotonin mirror those of low glutamate- NMDA function.

                                  SENSORY EFFECTS

• Over-Sensitivity to sounds, especially loud noises. Excessive jumpiness or even anxiety in response to sudden sounds or movements(1) (2).
• Visual distortions, height / depth alteration, hallucinations(3) (4).
• Words may appear out of place, or your perception of what you are reading may be entirely different. { e.g reading the third line thinking its the second} (5)
• Sensitivity changes to light, sedation or no response to darkness(6) (7) (8) (9). 
• Lack of pain sensation, or HYPO Algesia, some individuals with high serotonin display such a lack in pain perception/sensitivity that it mirrors the effects of those under the influence of PCP. Pain asymbolia can be misdiagnosed as high serotonin(10) (11).
• Tinnitus, ringing in ears(12)(13).
• Vertigo. Dizziness. Room spinning(14) (15).

                   BEHAVIORAL / MENTAL EFFECTS

• Delirium. Usually including abnormal forms of panic or worry along with various disperceptions(16) (17). 
• Depersonalization. Feeling out of place, out of body, or that events or surroundings are surreal(18)(19).
• Frequent or occasional episodes of psychosis, paranoia, pathology changes, and obsessional behavior(20)(21).
• Religious delusions and religious over-engagement. (some cult leaders are hypothesized to have elevated, but not toxic levels of serotonin)(22).
• Unexplained agitation or inner restlessness(23). 
• Dystonia, tic-like behaviors, punding; repetitive behaviors(24) (25) (26) (27).
• Frequent crying episodes in children, unwarranted panic or extreme anxiety(28).
• Low/Absent Libido(29)
• Emotional Anhedonia / Apathy / Blunt AFFECT (30) (31) (32) (33) (34)
• Jittery, nervous hands, tremors, impatient(35) (36) (37).
• Depression , despair, lack of motivation(38) (39). 
• Reading/Comprehension deficits(40).

                      PERIPHERAL / INTERNAL EFFECTS

• Persistent nausea, unexplained/stress induced; not due to motion sickness which is more acetylcholine based. (41) (42)
• Diarrhea/IBS Symptomology(43) (44) (45). 
• Cold hands / feet(46) (47) (48) (49).
• Lack of perspiration (sweating) or too much sweating(50) (51).
• Hyperhidrosis (52) .
• HYPERTHERMIA or HYPOTHERMIA , with a higher frequency of the latter(53) (54) (55). 
• Increased suspectibility to certain viral infections; polyoma virus susceptibility and influenza response alteration(56) (57) (58).
• HYPERTENSION, HIGH BLOOD PRESSURE (59)

                                                IN BLOOD WORK

-Low testosterone/On the low end of normal.

-High cortisol.

-High prolactin.

-High ACTH

-Hypo or hyperthyrodism (high T4/low TSH or the inverse)

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CLICK HERE FOR A NATURAL SEROTONIN BLOCKER TO BOOST LIBIDO and COGNITION

What does the INVERTED ACE symbolize, what is the meaning of an upside down (INVERTED) Ace of Spades

As an ordinary ace of spades symbolises/represents death (AKA the death card), an inverted one symbolizes resurrection, or life from death. It could also mean reincarnation. Traditionally, the ace of spades is the most powerful/significant card in the deck, and the one most associated with the "collective" win. Taken under great oath as the servant of the "master player". The Ace of Spades is a masculine symbol, the inverted ace would be seen by some as neither masculine nor feminine. 

Because, as pictured below, the ace is upside down, with the stem up, it could also indicate "heading to the ground" or "heading to hell" . Alternatively, given the ace of spades has a sharp tip, it can be seen as ready to spear the ground or attack that which it symbolizes. 

If the stem or "base" is up, it could also indicate one is exposed..or it could indicate one is firmly planted in the ground, and thus is standing firm and not budging. Is an obstacle that can't be moved, is not able to be influenced and thus "HEAVILY" stubborn and weighed down by that stubbornness which can not be moved.

Finally, as an ace of spades mimics the sexual attributes or is seen cojoined in description, it can be interpreted that the inverted ace is an asexual figure, or ..conversely, it could be seen as the "inversion" of sexual attributes, or a recreation of what is seen as sexuality. Considering the body of the symbol is in the ground, it could be seen as confined sexuality as well - or strictly engaged. It could also be seen as "locked in" or covered.

Thus the following definitions of the inverted ace of spades should be identified.

• Resurrection, reincarnation.
• Genderless, asexual. Non-human.
• Heading to the ground, "headed to Hell"
• Attacking hell. Stabbing that which is below.
• Inverting sexuality.
• Heavily implanted, heavily firm in effort. Immovable. 
• Locked in. 

Gangster / Chains' Meme's - Thug Boy Meme's / UNBLEMISHED MEME'S / MEME'S WITHOUT SITE LOGO

I don't have to pretend with all my CHAINS                       Everyone's a GANGSTER UNTIL 
                                                                    

          It's TIME TO DO GANGSTER SHIT!


I am the GANGSTER, NOT YOU!!

                                        !   MUGS YOU !

10 Rules for Assessing the Value of NeuroPharmacological Studies; How a Substance will Affect You & Why

HOW TO DETERMINE HOW A DRUG, CHEMICAL, OR NATURAL COMPOUND WILL AFFECT A LIVING HUMAN SUBJECT BASED ON A PUBMED STUDY OR REFERENCE & WHY


1.) Identify what is MISSING in the study before you register what is there.

• In other words , analyze unaccounted for parameter's or factors such as age, body weight, receptor integration etc.
• Look for determining cues of result fluctuation, or possible other reasons that could substitute or mimic the effect of the substance of question. Is it a significant difference than placebo and how many regions do the compounds effect?

2.) Determine whether the effects of a substance are primarily due to indirect 'shifting of receptor activity, or whether a direct effect of signal transduction modulation at the direct level. 

• Say you are talking about a 5-HT6 serotonin antagonist, and the study of it's pro cognitive effects. The receptor is positively coupled to adenylate cyclase. Therefore, does blocking it improve cognition because of the reduction of that enzyme or because the remainder of endogenous serotonin shifts to other receptors such as 5-HT5A, 5-HT4?

3.) REMAINDER RATIO. 

• Based on the above. Is the remainder of a neurotransmitter going to have a better chance to bind to cognitive improving receptors after the 5-HT6 is blocked? To figure this out, calculate the effects of each serotonin receptor, and the ratio of pro-cognitive to generally anti-cognitive receptors...e.g 5-HT4, 5-HT5A and 5-HT1A agonists are shown to improve cognitive function, whereas 5-HT3,2A,7A,1B,1D are anti-cognitive. 

4.) Distribution of Receptors; mapped to brain regions. 

• Specific brain regions have more of certain receptors than others in the human brain, thus we have to figure out whether the more substantial effects are due to the higher occurrence of binding by a particular compound, due to more receptors to bind to. E.G , is a 5-HT6 antagonist more effective than a 5-HT4 agonist because there are more 5-HT6 receptors in the hippocampi of the human brain.

5.) Receptor CO-LOCALIZATION :

• Are the effects of agonizing a certain receptor or antagonizing it due that receptor being cross-wired or colocalized with another, e.g 5-HT6 receptors are also present on GABAergic terminals therefore is antagonizing it an actual result of dual GABA inhibition due to cross over effect. Nerve terminals are incredibly complex, and heterodimization is another key factor in receptor functionality and interactions.

6.) Have an active knowledge of basic biochemistry principles. 

• Does the substance in mention have a phenyl group, hydrazide addition, acetyl group or addition - and thus based on it's chemical principles, is it permeable to the blood brain barrier? Additionally, is it's molecular mass small enough for it to be considered bioavailable or usable by the body? Does the substance meet Lipinsky's Rule of Five?

7.) ADMINISTRATION METHOD. 

• Is the substance orally active in the study? Do the chemical properties of the substance allow it to be orally available? 
• Additionally, is transdermal or injection a better method , or 'preferred' in the study?

8.) HALF-LIFE  / ACTIVE-LIFE

• Is the substance going to have translatable effects and a feasible half-life that doesn't infiltrate convenience? Thus display modern degrees of benefits.

9.) Whether the substance is metabolized by P-GLYCOPROTEIN, CYP34, and generally how the liver can process it.

• If the substance has benefits, but is broken down too quickly or requires additional enzyme modification for it to reach consistent blood levels, then it may not be a valuable substance standalone.

10.) Whether the substances true effects are based off of co-administration in the study or it's interactions with other undocumented factors (such as hormone replacement or modification).

The Story of the Lone Traveler, The Division of the Kingdom & A Wicked Will

There through hot and cold, in all terrain travelled there an interesting fellow, one who understood intricacies at a level not equivalent of his age - he was a divider , and a professional one.

This young man, largely a product and a test of nature - incited by the wicked will of his makers, he was born a Prodigy - with the perfect assortment of elements and imperfections. He was born with a channel of pride unforseen, and a desire that would simulate a magnitude of possibilities for the future.

He held within himself a pride that many would consider ancient and unsacred, a toxic drive, and was frequently incited as persuing non-human endeavors by those who looked over him....still, he appeared normal on the first years of his upbringing ---- except his mind was far ahead of his times.....and others would later understand the perceived transiency of this prodigal child was not a logical or intelligence deficit, but an emotional one....the scars of his making had bled a void in his heart - creating an attribute not similar to his peers.

He became a dishonor to those around him as a child - and a disruption as he instigated the powers of those below him, with minimal, but sufficient understanding....consequences were irrelevant on his plate - the only thing that mattered was IF it mattered to him. Born an objective oriented child - he didn't strive to the likeness of his peers, even despite understanding the pro's of communication, and from time to time enjoying such.....everyone to him was either unworthy or a means to an end.


This has remained true from his childhood to an adult - his communication skills bloomed as he got older - but only so that they may adapt him to the world that he had been subjected to enter - only so that he would set a new pace , as a mind like his was so unique, and yet so undisciplined, and yet disciplined...you see his life is a story of fluctuation from all extremes - from all weathers, from all temperaments, from all forms of dissatisfaction and to and from ultimate bliss and euphoria.

His story would further indicate him as a persevering , relentless , untouched, and yet unconditionally loving man despite it not being so normally instilled within his blood.....

This prodigal entity was a traveler, independent since just a few years, and one with a growing will, and two sides of that will. 

Despite being grown up criticized he was a fearsome soul, at times loving, and at times malevolent as a tyrant...his signature was to uphold things others didn't care much to believe in - but beyond the chaos he had encountered - his scattered mind was somehow always able to retain it's level of stability and logic....even if others didn't believe in it , this prodigal entity was driven to obtain - and driven to return to there from whence he came.

He was a student of the culture, but of adaptability - put at a disadvantage, and yet refusing a certain amount of advice - he was blessed and cursed with an insane stubbornness - one that only acknowledged it's own ascension the majority of days.
Time grew his will more selfish, and yet self-less ., but selectively. Time invigorated his soul with immense dissatisfaction with the world, and with those who have acted as dictators over him. 

Constraints rarely ever kept him down - for this entity would be unrivaled in persistence - he would get back up with an even more tempered, but aggressive will - second chances were a means of proving his original point - and making it firm that he will not stop until he obtains what he desires...no matter how many wills he has to bend, and how many rules he has to break - his desire would rule like a king, and eventually......his most grandiose statement "eventually no one will be able to stop me, and I will gain control over everything"...

Though I and others saw this as crazy, or abnormal..one concern remained, the pungency of his demeanor - was odd, different than others categorized into the same personna...it was as if he was able to call coincidences into action, and that he had a plan being kept from being heard, but internalized it with entire heart, it was like others close to him could almost feel the emanations of his dark side...and despite gaining the upper hand several times....he always kept it down within himself..his true plans....which would be revealed at a certain time..

His inhuman willpower would eventually take hold , and all circumstances would be summoned into place for his guaranteed ascension, one that is written and made formidable by those who would try to obstruct him, because you see, this prodigy, whenever obstruction had come against him - it only strengthened the entity that no one understood - because if they tried to, it would defy logic, it would defy what they knew.....if only they understood - they would understand that if you oppose this prodigy you bring pure evil out.....if you take from him , he will take from your soul in a manner and rate unprecedented....he is able to conjure an unending power based solely upon his own will.

What would later become, this man would succeed to anarchistic notions and politics to fit his chaotic willpower - he would cherish and liberate many people through his wise words, he would finally grasp a fair understanding of the things he had missed....there would be no hesitancy, for he always believed the things he had lost would be summoned back under the right circumstances....he was a child of immense insight - and vision that would make all brains in front, around or behind him - so incredibly transparent, that he would detect deception from a mild away...he could understand others, but others could only hope and believe that they understood him....

That's the most they could do - for he is sophisticated, not on the level of the Earthly , he is a soldier by intent - and made fearsome by a relentless altitude, he is connected and yet disconnected....he is dissociated and yet broadly associated, organized and yet mentally disorganized....

He is a fit for those of the past who had claimed a throne through unscrupulous methods....he is a lone traveler refusing to give up...constantly being put at a disadvantage and yet almost admiring the corrupt...yet he doesn't envision chaos all the time....he only does so when one strikes him first, then...oh but then, his wicked will is truly revealed.....one that is a consuming fire, ready and eager to obliterate all within his path, and one eager to gain unlimited power and perfection....the idea of an image of wicked pride - creating an  embodiment with the tools of the modern age he would quickly become a worldwide phenomenon....his aggression is passive-aggressive at this point, but appearing not at all to the masses...instead appearing innocent...while he secretly awaits his following......

He understands society to such an extent, not just from understanding himself, but from a fervent and stringent observation of similarities and patterns within everyone....he understands the minds of all - knowing exactly how to capture attention in a manner that everyone receives and is gracious for.....because when he finally makes his appearance to the masses - he is like a relief after a long period of dehydration, the crisp unmatchable taste of fresh water, the sighs of those relieved - he presents to the table all the words people could never find to say - and does so at a time where his beloved have already facilitated world anarchy...quickly allowing him as the ultimate healer and savior to emerge as the lone one who can no longer be ignored.....

This man, this prodigy, an intellectual and spiritual genius, with a prideful will and a relentless one - who would later succumb to the ultimate platform of notoriety, to destroy those who have forsaken and emerged against him...and all for the dominance of proving that original point "you can't stop me with your petty human willpower , I will gain all".

The dual fated personality is inevitably going to reach the epitome of that statement...because you see, he is the ultimate unifier after division, he is the ultimate logic when all seems to be lost - and yet he is the king of those who have been rejected by the pure, he is the ultimate necromancer - his will being so inhuman - it attracts and magnetizes everything he desires , almost solely because of his persistence , but because others underestimated him.....

He is now, that which remains integral to the final collective unity, and an image distorts the massive while some remain unsettled, constantly uttering in their own minds "who is this man, something's off about him".....but it's simply too late, those who attacked him and justified themselves spurred the very opposite of the response intented, and enabled his revenge against the entire world....

https://www.youtube.com/watch?v=hKNSTtiJjLA

Where there Shall be a Base Reference, there Shall be the Tools to Learn

One of the many common ways we as people learn, is by memorizing stupid little references from people, either third-party conversations or direct conversations - that may not have meant much at the time - but as we remember - we can use the words of seemingly wise men and women to influence further research.

Societal interaction is necessary, even if for a few moments to take a basis for research and learning into our lives - whether it's the words of patients in an exam room - or whether it is the motto of an artist - surely, we can learn a lot simply by looking at words and activating them as a reference..or as an excuse to think outside of the box.

In alternative words - that means that we can discover new area's of interest or expand on knowledge simply by investigating what people have said to us in the past, it only takes two things.

• Memory
• The Internet

However...it is not just through these references people can learn - but from posters, excerpts from books, studies ....that's how I got started on my quest for enlarging my bouquets of  knowledge - therefore what was the first investigation led to hundreds of others.

In contrast to years ago, I have much more knowledge than I ever even wanted to learn - all because life is so inexplicably amazing - and every event can be turned into a magnificent learning experience....what is externalized can be brought into you - and grow into something much stronger.

All that you need is a strong , untampered will  - one willing to go forward, and not willing to be sapped by arrogant partitions of humanity which have no role in your expansion. Ignore negativity, and play the role of the fiery lion except that your food is knowledge , accept that your food is knowledge, then paragraphs like what you see here will make sense because enthusiasm grows strong where there is a passion.