Strength can Not be Defined, Weakness is Not Always Blind, but Analysis must be Refined

The irony of weakness, is as same as the paradox of success, and at times, the definition of winning is parallel to the concepts embraced while losing.


What do we gain when we lose? Even if not right away, we gain experience. We often gain insight, after the dramatic/strong emotions run their presence.  When we "win" - providing we worked hard to win it, as in competition, we often afterwards, look over all the times of training or steps leading to the win - right after we absorb the great moments of uplifting vibes and the applause by little or large groups of people who may have witnessed the win.

So whether we lose or win - there is always that parallel, both cause us to look over things leading up to - just often with a different emotion at heart...the same can be said at winning the attention of another - that we either grasp because we know or because we don't know - or don't apply. 

Losing and winning are such vague and yet broad subjects, we can't always generalize - but we can see that the rarity of winning and the acceptability of losing both instill analysis (even subtle) in our minds/hearts...

The definition of winning is when everything worked in collaboration to emerge with the astound of our success - and the concepts embraced while losing is the originating analysis and all of what we learned along the way  - causing us to question things...so how are these similar?

Again, in both instances we are analyzing , even if not immediately, the steps that may have led up into that point. The reason there is a parallel, is because the definition of winning is adjacent to what we looked over while in progress, even while losing..they may be different roads but they all share the same tracks, so the message is along the way, no matter what the end result is.



You all have a gift, you all have seen and have some sort of grip of what your own abilities are - you all invision a day when you can apply these abilities , perhaps in a setting where you imagine yourself to dwell as a victor, but never can logically see yourself in that setting. 

You see, because many of you invision success without seeing the steps in between - but what's interesting, is just because you don't see the steps in between in the initial imagining, doesn't mean they aren't there - and perhaps you are...just looking over them?

I'm giving you the chance to understand yourself - if you are reading this, I believe in your abilities and what you can unlock - I believe in any sort of ego you have as a one-way trip to success - I believe that we all at times reject humility - but there's even many times and many places for some sort of assured ego - even if other's think it's crazy.....but let's not give just anyone a piece of ourselves unless it directly relates to or is on the path to our own victory. 

Productive society becomes so when new ideas emerge, but it also comes from understanding the basic principles .....and from understanding that.


A.)  Strength can not, and will never be defined.
B.) Weakness is not always weakness, and not always blind.
C.) Our current analysis must be refined in order to meet success.

A.) Strength can not, and will never be defined.

Before understanding your own strengths, remember this...

Most of your strengths can certainly become weaknesses, and if not that, then they can allude to your weaknesses; which is why your weaknesses should be shown in certain* circumstances, and only to people who you cherish, have studied thoroughly* or otherwise can trust assuredly.

  Thorough is defined by situation, not by some law or code, or guideline that tells what you what thorough is - thorough can never be universally the same - thorough is when you analyze to meet the criteria of a separate objective - and the analysis is custom tailored by you , for Your objective, therefore to obtain and / or defeat. Thorough is beyond self-discipline, thorough is rigorous adaptation to each separate situation , and seeing the worst and the best for each situation - but with emphasis on concluding what you deem fair or reasonable, STILL ALIGNED WITH YOUR OBJECTIVES.


Strength is not just a trait, but a potential - your strengths are what move you forward, they allow you to leap, and they are emanated from every ounce of your personality - they are what gives you spirit and what sets you apart from other people. Strength is what gets caught between others teeth , and in the fluttering of the thoughts of others when they speak about you, or remember you, respectively.  Strength as a whole can not be defined - because strength is constantly growing - leading us each to our individual destiny...strength is constantly making changes FOR US - strength is that part of us that emerges to prioritize the necessities and line them up in honor of what we believe in, and what we have learned. Strength is individual, but constantly transforming , not just transforming us, but transforming our minds - and bringing our goals and dreams to life.

Strength is reflected by the fragment's of our past - and strength has it's own life force - appearing without a shadow of a doubt - when we desire something - but strength is only submerged when we no longer believe in it.....the most successful people are those who REFUSE to SUBMERGE their strength, the most successful people tone their strength and keep on upgrading it until its evident that they are RELENTLESS, and believe in their strength so whole-heartedly that they aren't willing to let it succumb to another's benefit.

True strength may hold these traits, but it isn't defined by them, because strength can not be defined. However, it is outlined...outlined by perseverance, no matter what subject matter, no matter what venue of interest, strength emerges when people turn that strength into an ever-growing fire of belief, when strength is not advantageous, but instilled because of utter belief - it becomes contagious, it becomes innovative - it becomes the tears in people's eyes, how one can marvel, that one human willpower is able to do so much in so little time....

Merely because they believe, no matter how stupid it sounds to others, because definition doesn't need to be given, and strength doesn't need to be scripted, strength recruits the means vital to success

           
           

The Acceptance and Necessity of A Modified Interleukin-15; A Novel Non-Hormone Anabolic & Powerful Synergist of IGF-1

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research of INTERLEUKIN-15 & other novel anabolics, cytokines and anti-aging compounds.

Interleukin-15 is a complex cytokine (with structural similarity to IL-2) and growth factor that plays a huge role in skeletal muscle health and immunological responses.  IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine also induces cell proliferation of natural killer cells; cells of the innate immune systemwhose principal role is to kill virally infected cells. 

 It was discovered, cloned and characterized in 1994; being identified in human cultures/tissues and since then has been the subject of many important research advancements due to it's progressively astounding ability to impact many venues of human health(1).

It drew much attention in 1995; wherein an endocrinology report demonstrating it's application in skeletal myogenesis and myoblast proliferation, led to it ultimately being seen as a novel and potent non-hormonal anabolic "growth factor"(2) (3).

Continuous research also revealed INTERLEUKIN-15; to enhance immune responses and allow cells to more effectively battle the malaria virus, as well as other invaders/pathogens(4)(5).

1994 marked an important take-off and acceleration point for the study of IL-15; it was shown to increase natural T-killer cell production and efficiency, specifically in hunting abnormal cell developments (as in cancer).(6)

A 2011 study also elaborated on IL-15's ability to increase system t-Cell responses against foreign and abnormal cell collections, it was able to mediate an increased response to T-cell lymphomas and thus was seen as being a possible candidate for cancer research and treatment(7).

IL-15 also has shown the ability to modulate epidermal (skin, skin cells) immune cells/proliferation  and possibly reverse dermatitis and contribute to the natural blockade of epidermal invaders(8),
It is also extensively being studied in autoimmune conditions such as multiple sclerosis and in inflammatory bowel disease - where it shows some promise in alleviating these conditions, at least partly, or in some instances, in combination with other treatments(9).

As a further confirmation, IL-15 was again shown to have anabolic and myotropic effects in skeletal muscle - in this particular study - revealing the mechanism of action being antagonizing/halting proteolysis in muscle cells/tissues.

As a result of growing interest around this cytokine, and optimistic scientists in many instances recanting or bringing up IL-15 as a highly symbolic reference amongst anabolic research(10) (11), especially given the incline and attention to muscle wasting disorders, forumer's and fitness enthusiasts have taken further discussions regarding IL-15, under their wing and in highly popular threads(12)(13).

Certainly, and unlike other compounds in which may have questionable, or controversial support, IL-15 remains a candidate more likely to head the spotlight in anabolic research that doesn't involve hormones, or testosterone derivatives. Concern is mounting as many testosterone therapy clinics receive increasing scrutiny, and IL-15 is posed, quite reasonably as a powerful additive or alternative anabolic agent(14).

Particularly in unprecedented synergism with IGF-1 (Insulin-Growth-Factor-1) - where the combination of IL-15 & IGF-1 is noted to result in 5x the Anabolic Effects!!! (15) (16)


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THE NECESSITY OF Chemical Modifications In Order to Make IL-15 More Potent and Extend it's Half-Life in Order to Reach a new Level of Progression and Feasibility in Research and Practical Application
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Despite all of these benefits, the half-life and bioavailability factors of ordinary IL-15; cause it to remain somewhat inferior to other compounds aiming to dominate the particular venue of interest. This then necessitates a need for an extensive modification  in order for it to be plausible and significant in further scientific application and in practical use involving human subjects/volunteers(17) (18).

Under normal circumstances, this particular innovation would not have been brought to the table - however, Team TLR (Team TrueLife Research) has developed a modified and "optimized" IL-15; code named;                                      -----------------MOD-rhIL-15.-----------------

This is a proprietary modification that enhances it's potency by 125% and enhances the half-life by 290%.

Ractopamine - Not just another Beta-Adrenergic agonist; But Rather the "Alpha" of Beta Agonists

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research of Ractopamine & other beta-adrenergic based anabolic compounds.

Ractopamine is considered a feed additive to promote leanness in animals raised for their meat. Pharmacologically, it is a beta-adrenergic agonist. It is the active ingredient in products known as Paylean for swine and Optaflexx for cattle, developed by Elanco Animal Health, a division of Eli Lilly and Company, for use in food animals for growth promotion.
Ractopamine use has been banned in most countries, including the European Union, mainland China and Russia[1][2] while 27 other countries, such as Japan, the United States, Canada, and South Korea, have deemed meat from livestock fed ractopamine safe for human consumption.[3]

Commercial ractopamine is a mixture of all four possible stereoisomers.[4]

Beyond that fairly vague introduction, lies a much more interesting story, however. Let's first compare another beta-agonist; clenbuterol, with ractopamine.

Clenbuterol is a similar compound, known collectively as "CLEN" - this compound is used by bodybuilders to cut body fat tremendously , and to gain muscle and vascularity as well(!). Clen has a longer-half-life than ractopamine, but this also increases it's risk for toxicity, and makes alternative use of it trickier(!). 

Ractopamine's efficacy of beta-agonism and subsequent effects is quite impressive, and this underlies the reason for its use as opposed to other beta-agonists in livestocks...it has fast uptake into desired tissues, and it's effects are reliable even with consistent dosing(!). 

Other beta-agonists can run the risk of intertwining with the final product, despite the controversy surrounding ractopamine - it's less likely to appear in consumed meat than other similar chemicals(!). 

In terms of muscle growth, ractopamine shares a very potent anabolic effect with other agonists(!)....before we get into that  - lets first talk about WHY and WHAT.  Backtracking a little.


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RACTOPAMINE ; A BETA-ADRENERGIC AGONIST  

PATHWAY EXPLAINED

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A beta-adrenergic agonist is a substance that binds to and activates the beta-adrenergic (adrenaline) receptor - and thus acts similar to adrenaline but without touching the alpha-receptors(!).....most CLINICAL beta-agonists are even more specific, binding with only the beta-2-receptors - which have dense distribution in skeletal muscles and lung tissues(!).

Clinically, beta-2-agonists have efficacy and reliability in treating asthmatic conditions - and may aid in oxygen delivery both to the lungs and to other muscles lacking it(!) (!).

There are other beta-agonists being studied for obesity and for muscle-wasting disorders(!) (!).

Additionally, natural beta-agonists such as "HIGENAMINE" are often being thrown in to pre-workout supplements and being touted to increase the pump one would get from working out, and aid in cellular energy production as well as increasing protein synthesis in muscles(!).

None of this is wrong, however, there's always a question of HOW MUCH and whether half-lives of natural agonists are clinically relevant and / or sustainable for other conditions.

The pathway of beta-adrenergic receptors can be a little confusing, but basically these receptors are considered "POSITIVELY COUPLED" to "G-proteins" - which means when they are activated, they lead to a positive current exerted from G-proteins - which normally ensures and uses the cyclic Adenosine monophosphate (cAMP) system to activate the corresponding signaling cascade(!).

What this means is , essentially, beta-agonists raise cyclic AMP levels similar to forskolin, which then leads to all of the benefits of the cyclic AMP pathway such as enhanced lipolysis (fat-burning) and increased anabolism (muscle promoting/growth) and a higher metabolism - as well as increased steroidogenesis and testosterone secretion(!) (!).,

Cyclic AMP is considered a second messenger; and it leads to calcium channel activation and activation of PROTEIN KINASE A; which is a superfamily of heavy artillery enzymes involved in modulating and / or activating a variety of other subsequent enzymatical pathways(!).

Additionally, when this pathway is activated (such as with a beta-agonist) - nitric oxide levels also increase, which then leads to vasodilation and enhanced muscle protein synthesis and nutrient delivery / uptake into muscles(!).

Ractopamine has proven very effective in doing all of this(!)(!)....

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Ractopamine is NOT SOLELY a beta-agonist; but also a potent
TAAR1 agonist

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The trace-amine associated receptors ("TAAR")  are targets of amphetamines and other major
drugs, of the stimulant class, and this pathway is vital to their euphoric, energizing and anti-depressant effects ---- TAAR1 is a major signaling pathway, which involves the release and modulation of dopaminergic neuron networks - as well as other central signaling pathways(!).

The activation of TAAR1 gives ractopamine an advantage over other beta-agonists; causing it to be more "broad" and having additional anabolic / lipolytic activities than other beta-agonists....it also would have stronger anti-depressant effects - and thus a propensity to allowing more "mental edge" and stamina than other beta-agonists(!)...


Ractopamine may definitely acrue some other site-specific side-effects due to this property, however, reasonable doses are unlikely to carry significant side-effects - and the benefits may still be obtained by means of proper application, where other chemicals are not in the picture - and thus research can be conducted on only the pharmacological utility of ractopamine without the influence of an array of other compounds with variable half-lives(!) (!).


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CONCLUSIONS 

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Cleaner studies will reveal further use of ractopamine as a novel beta-adrenergic agonist; however they have to take into consideration now, the additional TAAR1 activity - and as such, subsequent studies are needed to define biological applications relating to each pharmacological effect...the properties must be isolated and analyzed as well as compared to other similar agents in order to further understand the use of ractopamine in study and in future subjects where not only livestock is involved.

Clearly, given the controversy, ractopamine has had a bad rap - but the environments and impractical/distorted use paradigms have certainly been responsible for coming concerns (though are legit) - it's a separate perspective that is needed under a more stable and less stressful environment in order to declare the verification of anabolic / lipolytic uses.

However, there is enough evidence as it is to see this agent as a powerful anabolic / lipolytic, but separate backgrounds and different subjects will be needed to properly evaluate side-effect profiles apart from mass-studies done in past times.

"Testosterone is not Testosterone" Long esters vs Short esters, Broscience Debunked.

 Yep you read it right, all the bro-science that's pushed around  forums about 'test being test' and 'ester only affects the half-life of the drug' is bullshit. Don't worry, I have my citations to back up these bold, but true claims. I've been getting a lot of PMs to get more information on the subject, as I've been dropping hints around the forums on my new thoughts and findings; so, I figured it's best to make a post so everyone can read this. We're going to talk about esters. This is something I've been researching about for the last 2 months or so, after using different esters of compounds and noticing different effects, both positive and negative. The common belief among the huge majorly of us is that “Testosterone is Testosterone”, the ester attached to the parent hormone just affects the half life. Well, after much research, I've found that this is just not the case. Different esters will greatly influence many different aspects of the drug's actions including:

1) Conversion to estrogen

2) Nitrogen retention/anabolic nature

3) Peak plasma levels of the drug

4) Level of HPTA suppression

5) And a few other things

How esters work

I'm sure most of you understand what an ester is, but here's a more in-depth explanation. Steroids are 4 ring structures with 19 carbon atoms. Here's a picture of what the Testosterone molecule looks like.

The easiest way to explain an ester is a time release mechanism. The ester prolongs the half-life of the drug. So pure testosterone, or, 'test no ester' is in and out of the system very quickly (less then a few hours). So multiple daily injections would be necessary for stable blood levels. This would obviously be very inconvenient and also very painful, so scientists decided to add a side chain or “ester” to extend the active life of the steroid. As a result, injection frequencies can be cut down. If you look at the picture above, you will see how the molecule is numbered. Notice the OH or hydroxyl group at the 17th position. That's necessary for the steroid to bind to the androgen receptor. This is where they add the ester. With this side chain or “ester” blocking the 17th carbon in the beta position, the steroid is temporally inactive. However, as soon as it gets into the blood stream, esterase enzymes come and hydrolyze the ester, or in other words remove the ester, which restores the hydroxyl group making the steroid active. Lastly, the longer the ester, the less water soluble it is and more fat soluble. Something that is more fat soluble is going to take longer be released from the deposit or “depot” the injection creates.

Long esters are more anabolic and will cause more muscle gain

Now that you have a better understanding of how esters work, we can talk about their actions and how “test is not test." First, we'll talk about how longer esters are more anabolic, and will cause more muscle gain than shorter esters. In 1954, a scientist named Reifstein and his team conducted a study comparing Testosterone Enanthate with Testosterone Propionate. The results of these studies were that Test Enanthate resulted in total nitrogen retention of 1.76g/day vs  Propionate only 1.02g/day. They also found that the duration of anabolic activity was 33 days with test e and 12 days with prop.(1) These were with the same doses 200mgs of each. Overall, the longer ester retains more nitrogen (muscle gain) per day then shorts, and remains active in the body for much longer. It doesn't take a rocket scientist to know that if something causes higher levels of nitrogen retention, and hangs around in your body longer, it's going to be more anabolic. Real life experience tells us the same. Think of a prop kicker, of 150mgs every other day, or just a prop cycle. I've done 6 week kickers while waiting for 500mgs a week of test e to kick in, and the results of the Propionate are not even close to the same as the long esters. Despite the same dosage AND 150mgs of prop, every other day  (525mgs total per week) actually contains more pure test then 500mgs of test Enanthate due to the ester weights,.

Plasma levels, suppression, and Estrogen

Scientists did a study on 3 different testosterone esters, short, medium and long esters. Their study showed that the short esters caused the greatest peak plasma levels of testosterone, next highest was the medium and lowest peak was the longest esters. However, they found that the long esters caused the greatest suppression on the gonadal axis and metabolic functions.(2) They even upped the short ester dose by 2-3 times and were still not able to replicate the suppression and metabolic effects of the long esters. This greater suppression is also due to the fact that longer esters convert more readily to estrogen, which will cause greater suppression which is what I’m going to get to next.

I'm sure a lot of you have noticed bloat is greater with long esters. Despite the fact the same people say 'test is test,' we don't typically use short esters for bulks and long esters for cuts. We use shorts for cuts and contest preps because they don't convert to estrogen to the same degree as longs do, in turn causing less water retention. Going back to the study, (2) estradiol levels were much higher with the group using long esters despite identical doses of the drug. In short, long esters cause a higher rise in estrogen. The study with the 3 different testosterone esters was done over a 28 week period. The shortest esters allowed for the quickest return of natural levels of hormones. Sperm count also remained the highest with the short esters. Concluding that short esters are less suppressible than long esters. Part of the reason why long esters are so much more suppressive is due to the rise in estrogen they cause. I'm not going to explain the negative feedback system of the HPTA here in depth, but basically the mechanism that tells the  HPTA to cease testosterone production is estrogen biding in the hypothalamus. The feedback system thinks ok estrogen is binding which is converted from testosterone so this reflects adequate levels of testosterone. So the HPTA shuts down.

Estrogen and IGF-1 and GH


I’m sure many of you know that using testosterone increases Growth hormone (GH) and Insulin like growth factor-1 (IGF-1) levels to a degree. But did you know that the increase in these hormones are due on estrogen aromatization? (3)(4) Going back, we know that long esters cause greater increases in estrogen, and estrogen increases GH and igf-1. So using long esters will result in greater muscle gain due to the factors I presented earlier, and also the increase in GH and IGF-1 levels that are much higher when using long esters. And as we all know HGH and IGF-1 are two very anabolic hormones. So higher levels of these hormones means more gains in size and strength.

So what about hormones/steroids other than Testosterone?

So now I've talked about how esters affect the effects of testosterone. Is it the same for all steroids with esters? Well, I've found some medical studies done on the different nandrolone esters. These studies had the exact same findings as the testosterone esters. The short ester  Nandrolone Phenylpropionate (NPP) had greater peak plasma levels then its long estered counterpart. And  suppression was greater with the long estered nandrolone deconate (deca-durabolin), and the anabolic effect was greater with the long ester (deca). Most people who have ran both Deca and NPP can say NPP causes less water retention. And the people I've talked to still say Deca is superior for muscle gain despite the same parent hormone, just different ester lengths. So its seems this the ester length and its effects on the drugs behavior remains true among many different hormones.

Summary

-Longer esters cause higher levels of estrogen
-
Longer esters cause more water retention
-
Longer esters cause more suppression of the HPTA
-
Longer esters cause higher levels of nitrogen retention (muscle gain)in other words are more anabolic

-Shorter esters cause higher peak plasma levels

More research on how this applies to other esterfied steroids. But from the short amount of reading I did do, it seems this applies to steroids that can aromatize, and can convert to Dihydrotestosterone. So the only ones that don't apply to this is Trenbolone, as it doesn't convert to DHT or estrogen, an Masteron as its already in DHT form. However, further research is needed, and that may be presented in my next post.   

 1.    Reifenstein, et. al. Studies comparing the effects of certain testosterone esters in man.J Am Geriatr Soc. 1954 May;2(5):293-8.. PMID: 13162731
    2.    Journal of Andrology, Vol. 24, No. 5, September/October 2003 Copyright © American Society of Andrology Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularisGERHARD F. WEINBAUER*, CARL-JOACHIM PARTSCH, MICHAEL ZITZMANN, STEFAN SCHLATT AND EBERHARD NIESCHLAG
    3.    [Veldhuis JD, Metzger DL, Martha Jr PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM 1997 Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 82:3414–3420
    4.    Keenan BS, Richards GE, Ponder SW, Dallas JS, Nagamani M, Smith ER 1993 Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 76:996–1001
    5.    Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection VolumeCharles F. Minto, Christopher Howe, Susan Wishart, Ann J. Conway, and David J. HandelsmanJ. Pharmacol. Exp. Ther., Apr 1997; 281: 93.

PGCL-OA & "Optimized" Analogues of PGF2A / PGCL = Extreme Anabolic Potential & Powerful Fat Burner w/Minimal Adverse Effects

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research of PGF2A & other prostaglandin based compounds.

-------------------------------------------------------------BUY Optimized PGF2A/PGCL at link below---------------------

http://teamtlr.com/tlr-oa-optimized-agents/64-pgcl-oa.html

------------------------------------------------------------------------------------------------TeamTLR HomePage--------------------


                                           ! Overview !
PGCL-OA even goes beyond ordinary PGCL (which is optimized in itself) - in that it has a much longer half life and more stability, allowing for significant, sustainable myotrophic effects and it also induces APOPTOSIS of FAT CELLS (in laymans's terms, in essence, KILLS FAT CELLS!!!).

TeamTLR's optimized PGCL~ compound, PGCL-OA [OA = Optimized Analogue], is a proprietary, ultra-potent, stable, and feasible Cloprostenol(PGCL) type compound - a form of a derivative of the naturally occurring prostaglandin PGF2A; PGCL-OA is optimized to provide superior benefits toward anabolism and lipolysis within enhancements that entail an extension of the half life to that of ~8 hours (PGCL/PGF2a both have very short half-lives) and roughly 50x the potency of the original PGF2A. 

It demonstrates strong anabolic and lipolytic effects; far superior to it's predecessors and is a valuable tool in anabolic research and research relating to myotropic compounds, as well as to that comprising obesity and lypolysis/fat burning directives.

It is prostaglandin based and thus not related to any steroid hormone - nevertheless, it's potential and validity in reviewing eicosanoid type pathways is set to be under the scope closely - as it presents a novel mechanism in myocellular modulation of a magnitude not previously seen.

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ANABOLIC PROSTAGLANDINS -
A lesson from another class Of Central Hormones
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In a book called the "The Zone Diet", Dr.Barry Sears elaborates on the importance of a set of fatty-acid based hormones dubbed "Eicosanoids" - which includes prostaglandins...

They are described as having immense effects  on not only fat metabolism, but oxygen delivery, vascular health and muscle growth and metabolism. He states that the key to reaching "the zone"; a state of anabolic and euphoric homeostasis within the body and mind - is to use a specific macro-nutrient balance that also includes special emphasis on supporting prostaglandin production by means of introducing or balancing omega-3 and omega-6 fatty acids in proper proportion.

Interestingly , the science does* back up some of what he sais(!), not only in terms of the significance of prostaglandins , but in reflection , there are drugs made from prostaglandins that have diverse utility in the treatment of multiple diseases and disorders; ranging from glaucoma(!), platelet aggregation/atherosclerosis to high blood pressure, to obesity to erectile dysfunction(!) (!) (!) (!)....

However, in terms of anabolic activity and in overall reliability on purely dietary methods of altering Prostaglandins, it is much more complicated and there are a few set backs , so to speak, in for next developments.

The reliability of using diet to specifically match up to the direct medical use of prostaglandins, or for athletic performance enhancement - OFTEN  falls very short of impressive....

The reason is because not everyone is capable of producing the same net amount of prostaglandins, and something as simple as taking aspirin or other NSAIDs can short out the production of prostaglandins significantly!

Thus, it is much more plausible and effective to introduce a synthetic prostaglandin, specifically one altered to have a longer-half-life and proper uptake into the intended muscle or organ.

This would ensure anabolic effects and proper utilization, and would bypass the need for all other factors to be orchestrated properly amongst miscellaneous biological pathways, some of which are debatable and so are the methods stating to "set their pace".

This all leads me to the main headline of this discussion.
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"Optimized" PGF-2-Alpha : The Ultimate Candidate  for Anabolism and Fat Loss?
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Of all the prostaglandins, and intermediates, one can be said that this one holds the most "anabolic leverage" - and may correspond directly to nitric oxide elevation far greater than even the most "extreme" N.O products on the market(!).

Additionally, this one in particular has complex rejuvenative effects on muscle tissue fibers, mediated through a unique pathway { NFATC2 } - which is a "nuclear factor" involved in cell growth - and thus these effects are both independent and additive of testosterone, growth hormone and other "muscle building hormones"(!) (!).

:"Optimized" Analogues have minimal Adverse Effects & Are Ideal in Scientific Applications:

Due to sustained action and core chemical modifications, an optimized analogue such as the one presented at the beginning of this article - is ideal for research use in respect of test subjects (QOL-scores) and may be a representation of valid and unique compounds - aside from those usually discussed (HGH, Test-E) and how they may provide new insight by simply altering the analogue a bit.

We can come from a window of opportunity, to a shining ray of light simply by "re-inventing the invention" , and with that, this unique analogue - PGCL-OA; a totally optimized and a largely side-effect free version of the PGF-2A derivative PGCL - it is a development worth taking interest to - and offers benefits and advantages not seen with the original compound...

Anything you can do to lower the strain of testing, yet still get the message across - is a valid investment and accelerates developments in that particular field. 

With amazing new developments and a recurring interest in neurobiological targets and anabolic research, it's specialized compounds such as PGCL-OA that will likely phase in the next big breakthrough.

PGCL-OA even goes beyond ordinary PGCL (which is optimized in itself) - in that it has a much longer half life and more stability, allowing for significant, sustainable myotrophic effects and it also induces APOPTOSIS of FAT CELLS.

That's usually a first in the eyes of science, because most fat burners are about "mobilizing" fat cells or altering adrenaline levels; which tends to produce more unwanted effects!

Best Male Sexual Enhancement Supplements/Compounds/Stacks/Methods

1.) Destroy PDE-5 mRNA 
Viagra, Cialis and Levitra, as well as natural alternatives, ICARIIN, Berberine, ginkgo biloba etc, all work to enhance erectile function by inhibiting the PDE-5 enzyme; however, only ICARIIN and BERBERINE inhibit genetic expression of this enzyme, leading to ...over time, permanent reduction in the levels of this enzyme!

"This can lead to beneficial vascular changes that are semi-permanent or permanent...however, you have to take the combination of Horny Goat Weed; Icariin extract and berberine for a minimum of two-three months for proper genetic "expressional" changes to occur."

               ::..:::RECOMMENDED PRODUCTS/EXTRACTS ARE BELOW:::..:: 
                         *BERBERINE*          ~ICARIIN~     
                                                            


2.)  Swedish Flower Pollen
Swedish Flower Pollen is a powerful supplement that is regarded by not only sexual health experts, but it is often proposed as a part of a fertility/ejaculate increasing stack or supplementation regimen.....even rumored to be a part of "Porn Star" stacks that enable one to "shoot the ropes"; describing the appearance of streaming ejaculate and substantial increase in semen volume as well sperm motility(!) (!).

As a natural supplement, it's very DIVERSE, it doesn't have one specific mechanism of action - but instead contains 1000's of nutritional and enzymatic components; most of which are specific to strengthening cellular integrity in the prostate and seminal ducts, but they also may deliver minerals and direct enzymes to the testis and thus increase uptake of steroidogenic enzymes which consequently will lead to enhanced fertility and sex hormone production at the testicular level.


              SWEDISH FLOWER POLLEN DISCUSSION AT ALLTHINGSMALE
                                                                     








3.)  Masteron (Drostanolone Propionate/Enanthate)
Masteron is an injectable dihydrotestosterone (DHT) compound; well known for it's off-label uses by bodybuilders as a potent aphrodisiac and erectile stimulant. It is known to help increase sexual aggression and can increase strength rapidly, making it ideal for stamina and "primal essence" . Additionally, according to studies, dihydrotestosterone levels are positively correlated with ability to achieve orgasm/ejaculate in men - as well as number of orgasms(!).

The benefits may also involve balancing estrogen levels which will promote a  supportive biological/psychological environment for confidence and sexual motivation(!).

Many men describe masteron as euphoric, balancing, and vigilance promoting. { Area1255's Recommended Masteron Store Click Here }


4.) Reducing the male refractory period and increasing total testosterone production by means of lowering prolactin naturally.

Dopamine and prolactin show an inverse relationship, science defines prolactin as inhibitory on testosterone production and on overall sexual desire , prolactin also increases latency or time til next ejaculate which is also known as the "refractory period".

One particular supplement that has stood the test of time is known as "USPLabs PowerFULL". It is shown to be a natural, over-the-counter dopaminergic supplement that can substantially lower prolactin levels without relying on the bodys own production of dopamine.

It supplies a direct precursor known as "L-DOPA"; a variant of this chemical, called LEVODOPA is actually a pharmaceutical drug for the treatment of parkinson's disease.
                                                                                                                                             



Alternatively, you could try dopaminergic drugs such as REQUIP or CABERGOLINE - which both can boost libido and eliminate male refractory period VERY QUICKLY. 

Requip can be bought --->  HERE

Cabergoline can be bought ---> HERE

5.) Lower serotonin and boost "neural networks" with a supplement called "Dark Shilajit".

Serotonin inhibits testosterone and dopamine, as well as spinal and hypothalamic nerve connections - leading to diminished or reduced sexual desire and erection quality....Shilajit is a long-lost "secret" used by those who desire maximum male hormonal dominance.

                                                                        

6.)  PT-141; A powerful melanocortin agonist that has shown efficacy in treating hypoactive sexual desire disorder (!) and erectile dysfunction(!) (!). It shows a strong libidogenic effect (libido boosting) in both men and women, and can last for several days. 
You can buy PT-141 securely HERE.

7.) Yohimbine HCL ; A powerful aphrodisiac for both men and women, but with more prominent effects on men. It can boost libido and stamina.

Prucalopride; A Safe EnteroKinetic Compound with Anti-Depressant and Nootropic Properties

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research of 5-HT4 agonist compounds.

Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class(1). It is a high-affinity (pK(i)  8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively) human serotonin 5-HT(4) agonist and is shown to alleviate chronic constipation and exert fast-anti-depressant effects(2)(3). It also is shown to have nootropic properties, and has benefits in reversing scopolamine related memory deficits(4).
Prucalopride has shown efficacy & safety in treating gastrointestinal disorders in both the elderly and the young(5)(!).

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NEURO-GASTRO-ENTEROLOGY Is Relevant & Ecstatic About 5-HT4 Agonist Compounds
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NeurogastroEnterology has been an exciting field, especially in recent years -  given the circumstances surrounding recurring states of chronic constipation have yielded the observation of nerve pathways playing a primary role in the pathophysiology of constipation; including but not limited to pseudo and chemical intestinal obstruction.

Low serotonin is also on the rise, and is a major contributor to constipated states, including those with a psychological manifestation(6)(7).

Prucalopride and other 5-HT4 agonists thus are exciting developments and substantial checkpoints in the successful treatment of chronic constipation, including those states normally considered to be "treatment resistant"(8).

Because they don't rely on the body's ability to produce serotonin, and the compounds; like prucalopride don't bind to any other serotonin receptors - these are incredibly useful research tools and even more significant treatment methods....they produce considerably fewer side-effects, to the point where a side-effect profile might as well be called almost completely absent(9) (10)(11).



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PRUCALOPRIDE & Other 5-HT(4) Agonists as Potentiators and Stand-Alone Anti-Depressants; Bridging the Gap to Safer, and Innovative Depression Treatments
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While SSRI's certainly have made their name all throughout, and represent a major area of study in terms of depression - they also have many side-effects; including negative effects on cognition and paradoxical worsening of depression in some patients(12) (13).

Apathy and anhedonia are not uncommon consequences of SSRI treatment, which can lead to deterioration in quality of life for many patients(14) (15).

Additionally, they are associated with a number of other unfavorable side-effects, such as tachycardia(fast-heart-rate), bradycardia (abnormally slow-heart-rate), blood glucose abnormalties, changes in lipid profiles, and hormonal spectrum disturbances; including metabolic syndrome, cortisol excess (hypercortisolism) and  reduced testosterone production and subsequent loss of libido(16) (17) (18) (19).

Part of the problem, again, with SSRI's is non-specificity in receptor targeting/modulation.

Studies published in 2007, 2010 and 2013+ are confirming that 5-HT4 agonists; including prucalopride - have immense anti-depressant effects, can enhance dopamine levels instead of decreasing it (20), and have vasodilating properties as opposed to vasoconstrictive or aggregating properties.

They also improve hippocampul function instead of degrading it, as SSRI's do, and thus are novel cognitive enhancing substances(21).



----------------------------------------------------------------------------------
Prucalopride Enhances Acetylcholine, Histamine and Dopamine Release ; 
                EVIDENCE FOR POTENT PRO-COGNITIVE EFFECTS
----------------------------------------------------------------------------------

Prucalopride , in a major study, was cited to significantly increase histamine, acetylcholine and dopamine in the hippocampus, as well as having positive effects in the reward circuitry of the striatum(22)(23).

Histamine and Acetylcholine are two primary area's of interest in regards to cognitive disorders; and are considered "two side's of the same coin"(24). Both of these neurotransmitters promote wakefulness, vigilance, and memory retention as well as active memory function...they also interact with each other a whole lot(25).

Two worthy quotes are displayed below.

The forebrain cholinergic neurons are localized in the nucleus basalis magnocellularis (NBM), the major source of cholinergic innervation to the neocortex and to the amygdala, and in the medium septum-banda diagonalis complex, which provides cholinergic inputs to the hippocampus (Mesulam et al. 1983; Woolf et al. 1984; Nicoll 1985). Basic and clinical studies have linked dysfunctions of these neurons to cognitive decline (Everitt and Robbins 1997; Givens and Sarter 1997). Their extensive loss is characteristic of the forebrain of Alzheimer's disease patients (Davies and Maloney 1976; Coyle et al. 1983; Kuhl et al. 1999), and anticholinergic drugs, such as scopolamine and atropine, produce learning and memory deficits in a variety of cognitive animal models (Deutsch 1971; Bartus and Johnson 1976; Ennaceur and Meliani 1992), and affect recognition memory in humans (Sperling et al. 2002; Sherman et al. 2003). Moreover, aged rodents display both cognitive impairments in many learning tasks (Ingram et al. 1994) and cholinergic deficits (Kubanis and Zornetzer 1981; Decker 1987; Gallagher and Colombo 1995). 

 Some histaminergic neurons also store neuroactive substances and related enzymes, such as GABA (Ericson 1991), glutamate decarboxylase (Takeda et al. 1984), adenosine deaminase (Senba et al. 1985), substance P (Köhler et al. 1985) and galanin (Köhler et al. 1986), in a species-specific manner (Airaksinen 1992), but the functional significance of these colocalizations is unknown at the moment. The morphological features of the central histaminergic system, with a compact cell group and a widespread distribution of varicose fibers, resembles that of other biogenic amines, such as norepinephrine and serotonin, thus suggesting that the histaminergic system may also act as a regulatory center for whole-brain activity (Wada et al. 1991). 

Considering the hypothalamus is a central brain region involved in hormone output, histamine is the subject of recent interests in neuro-endocrine disorders(26). Histamine is shown to be directly coupled to GnRH neurons(27), and thus, substances that activate it may help promote testosterone production, which may provide a further anti-depressant benefit(28).

Thus, an indirect increase in hypothalamic neuron activity (and hormone secretion) may represent one novel mechanism by which prucalopride may exert additional anti-depressant and pro-cognitive effects(29).



------------------------------------------------------------------------------------
PRUCALOPRIDE Potently Increases cyclic Adenosine Monophosphate (cAMP)
-------------------------------------------------------------------------------------

Further supporting the clinical benefits of prucalopride on depression and on the hormonal axis, is it's ability to (much like forskolin) - potently increase cellular and central levels of cyclic AMP; which will lead to enhancement of metabolism and mobilization of blood glucose...(30) (31)

Stimulating cyclic AMP may lead to a net increase in steroidogenesis and an increase in overall thermal metabolism, which adds to the benefits and diversity of prucalopride and other 5-HT4 agonists(32) (33).

While there are no direct studies relating 5-HT4 agonists to testosterone secretion, it may be replicated in future studies where cAMP-based interactions are further examined(34) (35).



In summary, prucalopride may yield the following benefits.

• Alleviate multiple forms of treatment resistant constipation and pseudo-gastro-intestinal obstructions.
• Act as a potent and fast acting anti-depressant. 
• Act as a synergist for other anti-depressants.
• Improve Vigilance and cognitive function.
• Reverse scopolamine related memory impairment and augment SSRI actions in the hippocampus.
• Increasing levels of the valuable second messenger ; cyclic AMP.
• Increasing dopamine, acetylcholine, and histamine levels.
• As a potential metabolism enhancing compound.

Natural VS Pharmaceutical Aromatase Inhibitors (AI's) ; A Comparison

Certainly, messing around with odds while on cycle, or on testosterone replacement therapy, is a very risky and foolish "shot in the dark"  - ESPECIALLY when it has to do with the delicate balance of  E2 ; Estradiol/Estrogen .....in Men, an excess of estrogen can easily diminish the benefits of testosterone replacement, and even for those who aren't hypogonadal, excess estrogen can hinder the functionality of testosterone.

Conversely, low E2 can cause problems with joints and lipid profiles, as well as blood pressure issues and possible depression/apathy.


In either case, for us to make an accurate assessment - we have to know the specifics of the variety of tools of available to us. Natural aromatase inhibitors are either very effective, or very, VERY sketchy. 

In fact, there's very few "natural AI's" (out of hundreds available) that I've found to actually reduce E2 in blood work...and with some of these formula's constantly changing...it's hard to know what to think sometimes...

However the bigger issue with natural AI's , is dependability and significance in ratio with the problem....assume excessive estrogen is an issue - natural AI's can be helpful, but likely won't remedy a "true" estrogen problem, especially where hormone replacement therapies are involved.

Additionally, the half-lives of most natural aromatase inhibitors are very poor in comparison to their synthetic counterparts, therefore, a consistent degree of modulation would become even trickier, and more inconvenient....

The average bear may also not feel like taking a set amount of pills several times a day....especially when the ingredients are questionable and most of these pills don't contain a certificate of analysis to verify purity and consistency in the proposed "AI Component".

You also have to differentiate and isolate the ingredients in most cases, figuring out which part of the proprietary blends are doing most of the work...this is considerable hardship and can be extremely frustrating.

With pills like "ADEX" - or arimidex, you get a solid functionality and guaranteed reduction in E2 , without worrying about purity or the evidence of multiple ingredients and their possible interactions and questionability of long-term safety profiles.

Now I'm not saying that natural AI's don't work - I'm simply saying that for more severe estrogen issues - they can be unpredictable...if you  are simply looking to drop estrogen a few points, then adding some natural AI's may be beneficial, especially while on a "CUT". 

I don't recommend natural AI's for well-defined and diagnosed E2 issues of moderate-high severity. I also urge you to thoroughly research the capacity of any natural AI's, sifting through bro-science and sho-science can be very annoying....

**OTHER RESOURCES / SUPPORTING LINKS**

Optimizing Testosterone Levels in Aging Men

By Paul D. Navar, MD

Natural and Pharmaceutical Estrogen Blockers for Men

Where to buy Brand Name Arimidex (ADEX) Online (real adex,not research chem)

Where to buy Legit Letrozole Online